TNF‐α induced variability of ICAM‐1 expression in skeletal muscle microvasculature

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Variability in training-induced skeletal muscle adaptation

When human skeletal muscle is exposed to exercise training, the outcomes, in terms of physiological adaptation, are unpredictable. The significance of this fact has long been underappreciated, and only recently has progress been made in identifying some of the molecular bases for the heterogeneous response to exercise training. It is not only of great medical importance that some individuals do...

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Investigation of the RBP4 and GLUT4 gene expression in skeletal muscle of STZ induced diabetic rats following aerobic exercise training

Background: Type2 diabetes is a metabolic disease that is rapidly increasing in the world. GLUT4 and RBP4 are factors that play a role in glucose uptake. This study aimed to investigate the effect of moderate-intensity continuous training on RBP4 and GLUT4 gene expression of soleus muscle in STZ induced diabetic rats. Methods: This experimental study was conducted between May and September 201...

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Development and adaptability of microvasculature in skeletal muscle.

In skeletal muscle, the size of the capillary bed is adapted to the type of muscle metabolism and can be altered by adaptation to different environments or increased activity. Muscle fibres with high aerobic metabolism have more capillaries, and an increase in aerobic metabolism is usually followed by capillary growth. It is assumed that local hypoxia - created by increased demand for oxygen du...

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HIGHLIGHTED TOPIC Signals Mediating Skeletal Muscle Remodeling by Activity Variability in training-induced skeletal muscle adaptation

Timmons JA. Variability in training-induced skeletal muscle adaptation. J Appl Physiol 110: 846 – 853, 2011. First published October 28, 2010; doi:10.1152/japplphysiol.00934.2010.—When human skeletal muscle is exposed to exercise training, the outcomes, in terms of physiological adaptation, are unpredictable. The significance of this fact has long been underappreciated, and only recently has pr...

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Objective(s): Soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex proteins are involved in membrane trafficking. The expression of isoforms of SNAP-23, syntaxin-4, and VAMP-2 is significantly done in skeletal muscles; they control GLUT4 trafficking. It is believed that type 2 diabetes could be caused by the modifications in the express...

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ژورنال

عنوان ژورنال: The FASEB Journal

سال: 2006

ISSN: 0892-6638,1530-6860

DOI: 10.1096/fasebj.20.4.a702-d